Bipolar-to-monopolar spindle collapse in human eggs.

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Bipolar-to-monopolar spindle collapse in human eggs.

Mol Reprod Dev. 2012 Jul 9;

Authors: Duncan FE, Hornick JE, Woodruff TK


The bipolar spindle is an integral part of the cell division machinery required for faithful chromosome segregation. During meiosis in the mammalian females, this machinery must function sequentially during a reductive (meiosis I) and equational (meiosis II) cell division to ultimately produce a haploid egg that can be fertilized and give rise to the next generation. Errors in this process can result in aneuploidy (incorrect chromosome number), which can have adverse reproductive outcomes such as infertility, miscarriages, and birth defects. Mol. Reprod. Dev. © 2012 Wiley Periodicals, Inc.

PMID: 22777649 [PubMed - as supplied by publisher]