Scientists have discovered four new genes associated with an increased risk of late-onset Alzheimer’s disease. The findings will help researchers explore new therapies and allow doctors to better predict who will develop the disease.
The Alzheimer’s Disease Genetics Consortium conducted the research in collaboration with 44 different universities and research centers, including Northwestern University. The study, published in the current issue of Nature Genetics, is the largest of its kind.
The results of the study double the number of genes currently known to contribute to Alzheimer’s. Of the four genes previously confirmed, the gene for apolopoprotein E-e4, called APOE-e4, has the largest effect on risk. The genes discovered in this study are called MS4A, CD2AP, CD33 and EPHA1.