Scientists discover cause of immature eggs’ death from cancer drug and how to prevent it
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CHICAGO — Young women who have cancer treatment often lose their fertility because chemotherapy and radiation can damage or kill their immature ovarian eggs, called oocytes. Now, Northwestern Medicine® scientists have found the molecular pathway that can prevent the death of immature ovarian eggs due to chemotherapy, potentially preserving fertility and endocrine function.
Scientists achieved this in female mice by adding a currently approved chemotherapy drug, imatinib mesylate, to another chemotherapy drug cisplatin.
The results will be presented Monday, June 17, at The Endocrine Society’s 95th Annual Meeting in San Francisco.